Agoseris hirsuta occurs primarily on grassy hills in the San Francisco Bay area and extends both north and south in the Coast Ranges. It has been treated as A. apargioides subsp. or var. apargioides in recent floras. Agoseris hirsuta is closely related to A. apargioides and A. heterophylla. Morphologically, it is similar to A. heterophylla var. cryptopleura. Putative hybrids with A. apargioides, A. grandiflora var. grandiflora, A. heterophylla var. cryptopleura, and A. retrorsa have been collected.